Solubility of triclabendazole as a factor determining the activity of its solid dispersions with polymers

The purpose of the research is to study solubility triclabendazole-based (TCB) solid dispersions (SD) and polymers obtained under optimal conditions mechanochemical technology; confirm chemical stability a TCB substance by HPLC method both during its SD preparation their storage. Materials methods . used substance, polyvinylpyrrolidone (PVP), arabinogalactan (AG), licorice extract (LE) that contained 25% glycyrrhizinic acid (GA). For machining, initial components were taken in 1 : 9 weight ratio machined an LE-101 drum mill on rolls with rotating at speed 55–60 rpm 17 process module for 6 hours sampling evaluate stability. sample evaluated these samples HPLC. Results discussion machining selected corresponding SDs following compositions: PVP (1 9), AG 4.5 4.5) LE which free-flowing powders enhanced (up 34). evaluation previously showed decreased slightly over time. example, decrease 9) was observed from 10 8 (the after 2 h machining) 23 18 4 machining). earlier.